ceesdekker.net - An Overview
ceesdekker.net - An Overview
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, Groningen researchers current the outcome in their initiatives for making labs extra sustainable and supply strategies for other labs.
2007, to start with actual-time detection of strand Trade in homologous recombination by RecA; discovery of the reduced persistence size of finishes of microtubules; and settled the system of biosensing with carbon nanotubes
2015, discovery that condensin can be a very adaptable protein framework; and very first detection of DNA knots utilizing nanopores
Instance (3) of bending configurations in 3D simulations of DNA rods on nanopores. A part of the membrane is proven in gray, the rim on the pore is highlighted in red, in addition to a 3D rendering with the motion of your DNA rod is shown.
Considering the fact that 2000 he moved to solitary-molecule biophysics and nanobiology, with exploration from DNA supercoiling reports of nucleosomes and DNA fix proteins to DNA translocation via nanopores. Recently his exploration has focused on studying mobile division with microorganisms on chip, whilst his top fascination is inside the direction of noticing synthetic cells.
Atomic force microscopy displays that vaccinia topoisomerase IB generates filaments on DNA in a very cooperative fashion
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Presently, we also understood that it ought to be attainable to work with an individual semiconducting carbon nanotube to produce a transistor — and we set out to make it. We stretched individual semiconducting nanotubes throughout metallic electrodes and applied the underlying silicon substrate like a gate electrode, establishing The essential a few-terminal format of a field-outcome transistor (Fig.
Given that 2000 he moved to one-molecule biophysics and nanobiology, with investigation from research of DNA loop extrusion and supercoiling to DNA translocation as a result of nanopores. Far more lately his investigate has focused on researching chromatin construction and mobile division with germs on chip, when he is additionally seeking to in the end Establish synthetic cells from The underside up.
Cees Dekker is Distinguished College Professor at TU Delft. Properly trained to be a physicist, he pioneered nanotechnology with lots of discoveries on carbon nanotubes during the nineteen nineties. Considering the fact that 2000, he moved to one-molecule biophysics and nanobiology. His present-day exploration focuses on (i) nanopores for protein sequencing; (ii) chromosome framework, particularly SMC motor protein; and (iii) creating a residing synthetic mobile from lifeless molecules. Dekker is definitely an elected member in the KNAW and fellow towards the APS as well as the IOP.
2008, initial observation of protein-coated DNA translocation via nanopores; resolved the origin of the electrophoretic force on DNA in nanopores; discovered an important velocity maximize of microtubules in cees dekker electric powered fields; learned an anomalous electro-hydrodynamic orientation of microtubules; and solved the origin of sound in carbon nanotubes in liquid
Example (two) of bending configurations in 3D simulations of DNA rods on nanopores. A portion of the membrane is demonstrated in gray, the rim in the pore is highlighted in pink, as well as a 3D rendering of the motion of your DNA rod is shown.